This test is used to measure the levels of all Total Complement. CH50 can be used to assess the integrity of the classical pathway of the immune system.
A normal CH50 level indicates that all the components of the C1 through C9 are present; however, even in the presence of a normal CH50, the absolute levels of some complement components (eg, C3 or C4) can be significantly (50% to 80%) lower than normal without affecting CH50 activity. This is because normal serum contains C3 and C4 in substantial excess of that required to yield a normal result for CH50. Depletion of alternative factors is not detected. For this reason, it may be necessary to measure individual complement components.
The most common use of CH50 is to Evaluate and follow up SLE (systemic lupus erythematosus) patient's response to therapy; may predict disease flare in SLE; evaluate for complement component deficiency; evaluate complement activity in cases of immune complex disease, glomerulonephritis, rheumatoid arthritis, SBE, cryoglobulinemia. The CH50 assay mainly evaluates the classical pathway.
Monitoring therapy of SLE, suspected complement deficiency.
No special preparation is necessary prior to blood sample collection.
Complement, Total (CH50) -
Quantitation of total functional serum complement
Estimated Turn Around For Results:
2-10 Business Days
For an exact turnaround time for results, please contact us at Personalabs and we will contact the lab on your behalf as turnaround times vary depending on testing location or lab testing provider.
To be able to use our service you must abide by our Refund Policy.
Refunds are only permitted prior to submission of specimens for testing.
You may request to cancel your lab order within seven (7) days of the date of purchase to receive a refund.
Your refund will be reduced by $15 to cover the cost of the doctor's order as well as the cost of processing your request to charge and refund your credit card.
No refunds are given after seven (7) days.
However, a credit can be issued to your account, less the $15 fee, and can be used towards your next order.
After visiting the lab and having your blood drawn, no refund can be made.
If for any reason Personalabs is unable to process your specimen, you will receive a full (100%) refund for the test(s) not performed.
Lab orders are only valid for up to six (6) months from the purchase date at which point any unused lab orders are purged from our system. If you wish to reinstated your lab order, you will be charged a $15 fee to cover the cost of the doctor's order as well as the cost of processing your request.
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To process your refund, you must first request via email by selecting “Send a Message” on the Contact Us tab section.
Please provide your Order information and reason for the refund.
Please allow 24 to 72 hours to process your claim.
After we accept your refund request, you will be issued a refund via the same payment method originally used to place the order (Debit Card, Credit Card, HSA or PayPal).
The refund amount will be composed of the original purchase price minus $15 of your original charge to cover the cost of the doctor's order as well as the cost of processing your request to charge and refund your credit card.
You will be sent an email confirming receipt of the return and your credit.
Please allow 3-5 business days to reflect in your account.
|Normal||Normal||Calcium regulation system functioning OK|
|Low||High||PTH is responding correctly; may run other tests to check for other causes of hypocalcemia|
|Low||Normal or Low||PTH not responding correctly; probably have hypoparathyroidism|
|High||High||Parathyroid gland producing too much PTH; may do imaging studies to check for hyperparathyroidism|
|High||Low||PTH is responding correctly; may run other tests to check for non-parathyroid-related causes of elevated calcium|
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