This test is used to measure the levels of all Total Complement. CH50 can be used to assess the integrity of the classical pathway of the immune system.
A normal CH50 level indicates that all the components of the C1 through C9 are present; however, even in the presence of a normal CH50, the absolute levels of some complement components (eg, C3 or C4) can be significantly (50% to 80%) lower than normal without affecting CH50 activity. This is because normal serum contains C3 and C4 in substantial excess of that required to yield a normal result for CH50. Depletion of alternative factors is not detected. For this reason, it may be necessary to measure individual complement components.
The most common use of CH50 is to Evaluate and follow up SLE (systemic lupus erythematosus) patient's response to therapy; may predict disease flare in SLE; evaluate for complement component deficiency; evaluate complement activity in cases of immune complex disease, glomerulonephritis, rheumatoid arthritis, SBE, cryoglobulinemia. The CH50 assay mainly evaluates the classical pathway.
Monitoring therapy of SLE, suspected complement deficiency.
No special preparation is necessary prior to blood sample collection.
Complement, Total (CH50) -
Quantitation of total functional serum complement
Estimated Turn Around For Results:
2-10 Business Days
For an exact turnaround time for results, please contact us at Personalabs and we will contact the lab on your behalf as turnaround times vary depending on testing location or lab testing provider.
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Refunds are only permitted prior to submission of specimens for testing.
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After we accept your refund request, you will be issued a refund via the same payment method originally used to place the order (Debit Card, Credit Card, HSA or PayPal).
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Please allow 3-5 business days to reflect in your account.
|Normal||Normal||Calcium regulation system functioning OK|
|Low||High||PTH is responding correctly; may run other tests to check for other causes of hypocalcemia|
|Low||Normal or Low||PTH not responding correctly; probably have hypoparathyroidism|
|High||High||Parathyroid gland producing too much PTH; may do imaging studies to check for hyperparathyroidism|
|High||Low||PTH is responding correctly; may run other tests to check for non-parathyroid-related causes of elevated calcium|
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